No. 24 Iowa jumped into the top 25 of the college football rankings after winning its first three games of the season. The Hawkeyes will face their toughest test so far when they travel to No. 7 Penn State on Saturday night in a Big Ten on CBS (7:30 p.m. ET) matchup during the Week 4 college football schedule. They have scored at least 20 points in all three of their games, but they are 14.5-point underdogs in the Week 4 college football odds from SportsLine consensus. Should you back them with your Week 4 college football bets?

No. 19 Colorado escaped with a double-overtime win over Colorado State last week, but Deion Sanders and the Buffaloes are expected to suffer their first loss of the season when they face No. 10 Oregon on Saturday. Coach Prime’s team is a 20.5-point underdog in the latest Week 4 college football spreads. Before locking in any Week 4 college football picks on those games or others, be sure to see the latest college football predictions from SportsLine’s proven model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Since its inception, it has generated a stunning profit of nearly $2,500 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

Now, it has turned its attention to the latest college football odds for Week 4 and locked in picks for every FBS matchup. Head here to see every pick.

Top college football predictions for Week 4

One of the college football picks the model is recommending for Saturday: Baylor (+14.5) easily stays within the spread against No. 3 Texas in a 7:30 p.m. ET kickoff at McLane Stadium. Texas might have defeated Wyoming by 21 points last week, but the game was tied heading to the fourth quarter. The Longhorns’ Week 2 win over Alabama is not looking as impressive as it once was either, as the Crimson Tide struggled against South Florida last week.

Sophomore quarterback Quinn Ewers is coming off his worst outing of the season for Texas, completing 11 of 21 passes for just 131 yards against Wyoming. Baylor led in the fourth quarter against No. 12 Utah two weeks ago before blowing out LIU last week. The Bears are 8-2-1 against the spread in their last 11 games as underdogs, and they are covering the spread in well over 60% of the model’s latest simulations. 

Another prediction: Arkansas (+18) plays a competitive road game at No. 12 LSU on Saturday at 7 p.m. ET. LSU will have trouble pulling away against an Arkansas offense that has scored at least 28 points in all three of its games this season. Quarterback KJ Jefferson has completed 55 of 77 passes for 629 yards, six touchdowns and just one interception while rushing for 80 yards and another score. 

Junior running back AJ Green is averaging 6.8 yards per carry, racking up 190 yards and two touchdowns on 28 attempts. LSU took advantage of a rough performance from Mississippi State’s offense last week, but the Tigers are unlikely to have the same success this week. SportsLine’s model has Jefferson accounting for nearly 250 yards and two touchdowns in the latest simulations, which is a big reason why the Razorbacks are covering the spread 60% of the time. See which other teams the model likes here.

How to make college football picks for Week 4

The model has also made the call on who wins and covers in every other FBS matchup in Week 4, and it’s calling for several underdogs to win outright. You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence, and which underdogs win outright? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned nearly $2,500 in profit since its inception, and find out.

College football odds for Week 4 top games 

See full Week 4 college football picks, odds, predictions here

Thursday, Sept. 21

Georgia State at Coastal Carolina (-6.5, 62.5)

Friday, Sept. 22

Wisconsin at Purdue (+7, 54.5)

NC State at Virginia (+9.5, 45.5)

Boise State at San Diego State (+7, 45.5)

Air Force at San Jose State (+3.5, 47)

Saturday, Sept. 23

Oklahoma at Cincinnati (+14, 60.5)

Florida State at Clemson (+1.5, 55)

Ole Miss at Alabama (-7, 55)

UCLA at Utah (-5, 51.5)

Colorado at Oregon (-20.5, 72)

Arkansas at LSU (-18, 55.5)

Ohio State at Notre Dame (+3, 54)

Iowa at Penn State (-14.5, 41.5)

Texas at Baylor (+14.5, 51.5)

North Carolina at Pittsburgh (+7, 50)